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Bax activator compound 106
CAS No. 1638526-94-9
Bax activator compound 106 ( ZINC14750348 )
Catalog No. M12474 CAS No. 1638526-94-9
A specific, small molecule Bax agonist that promotes Bax-dependent but not Bak-dependent apoptosis.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 476 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameBax activator compound 106
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NoteResearch use only, not for human use.
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Brief DescriptionA specific, small molecule Bax agonist that promotes Bax-dependent but not Bak-dependent apoptosis.
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DescriptionA specific, small molecule Bax agonist that promotes Bax-dependent but not Bak-dependent apoptosis; alters Bax protein stability in vitro and promotes the insertion of Bax into mitochondria, leading to Bax-dependent permeabilization of the mitochondrial outer membrane; induces significant cell death and caspase 3/7 activation in Bax-expressing cells, inhibits the growth of transplanted tumors as a single agent.
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SynonymsZINC14750348
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PathwayAngiogenesis
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TargetBcl-2
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RecptorBcl-2
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Research Area——
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Indication——
Chemical Information
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CAS Number1638526-94-9
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Formula Weight488.63
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Molecular FormulaC29H36N4O3
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(C1=NN(CC2=CC=CC(OC)=C2)C3=C1CN(CC4=CC=C(C)C(C)=C4)CC3)N5C[C@H](O)CCC5
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Chemical Name5-[(3,4-dimethylphenyl)methyl]-1-[(3-methoxyphenyl)methyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-3-ium-3-yl}-[(3R)-3-hydroxypiperidin-1-yl]methanone
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Daniele S, et al. ACS Chem Neurosci. 2017 Apr 11. doi: 10.1021/acschemneuro.7b00023.
2. Zhao G, et al. Mol Cell Biol. 2014 Apr;34(7):1198-207.
2. Zhao G, et al. Mol Cell Biol. 2014 Apr;34(7):1198-207.
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