Bax activator compound 106 ( ZINC14750348 )

Catalog No. M12474 CAS No. 1638526-94-9

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Product Name

Bax activator compound 106
Note

Research use only, not for human use.
Brief Description

A specific, small molecule Bax agonist that promotes Bax-dependent but not Bak-dependent apoptosis.
Description

A specific, small molecule Bax agonist that promotes Bax-dependent but not Bak-dependent apoptosis; alters Bax protein stability in vitro and promotes the insertion of Bax into mitochondria, leading to Bax-dependent permeabilization of the mitochondrial outer membrane; induces significant cell death and caspase 3/7 activation in Bax-expressing cells, inhibits the growth of transplanted tumors as a single agent.
Synonyms

ZINC14750348
Pathway

Angiogenesis
Target

Bcl-2
Recptor

Bcl-2
Research Area

——
Indication

——

CAS Number

1638526-94-9
Formula Weight

488.63
Molecular Formula

C29H36N4O3
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(C1=NN(CC2=CC=CC(OC)=C2)C3=C1CN(CC4=CC=C(C)C(C)=C4)CC3)N5C[C@H](O)CCC5
Chemical Name

5-[(3,4-dimethylphenyl)methyl]-1-[(3-methoxyphenyl)methyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-3-ium-3-yl}-[(3R)-3-hydroxypiperidin-1-yl]methanone

1. Daniele S, et al. ACS Chem Neurosci. 2017 Apr 11. doi: 10.1021/acschemneuro.7b00023.
2. Zhao G, et al. Mol Cell Biol. 2014 Apr;34(7):1198-207.

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